BRAIN-iPSC
Modelling how polygenic risk for brain disorders affects human stem cell-derived neurons.
Explore project ↗University of Helsinki · FIMM · HiLIFE · NC
We are interested in cellular genetics and the cellular basis of developmental and other brain-related disorders. We use human induced pluripotent stem cells (iPSC) as models, and combine computational and experimental methods to study how genetic variation causes variability in cell phenotypes and contributes to differential susceptibility to diseases, both common and rare.
Explore our research ↗Modelling how polygenic risk for brain disorders affects human stem cell-derived neurons.
Explore project ↗Investigating molecular variation in iPSCs from individuals with rare genetic diseases.
Explore project ↗Comparing patient-derived and engineered cells to understand the influence of genetic background.
Explore project ↗Following neuronal differentiation to study the effects of mutations in chromatin regulators.
Explore project ↗Today, Marc Carrillo Pérez represented the Kilpinen Group at the Nordic EMBL Partnership Meeting in Umeå, presenting his work on modelling early neurodevelopment in RNU4-2-associated disorders.
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